Our PAD™ Technology enables a new class of creams and eye drops (PAD™ Vehicles) that offer a number of unique advantages in the development of new topical therapies for chronic inflammatory conditions.
PAD™ Technology characteristics
PAD™ Vehicles are special made oil-in-water dispersions in which the internal oil phase is stabilized by encapsulation in a thin yet robust aqueous film of surfactants. The manufacturing of PAD™ Vehicles requires no special excipients and affords unsurpassed versatility in selection of pharmaceutical grade oils, solvents, surfactants, preservatives and other ingredients of choice. In a nutshell each PAD™ droplet maintains its own physical-chemical stability without the need of excessive presence of surfactants in the external phase. Consequently, PAD™ formulations are characterized by very low amounts of surfactants compared to conventional creams and lotions. PAD™ Technology offers an expanded formulation space and PAD™ Vehicles can be made in a variety of dosage forms.
PAD™ Vehicles are tailor-made to meet the target product profile for a specific product candidate. Key features of the PAD™ Vehicles are (i) superior penetration, (ii) improved solubility of API’s, (iii) stability of difficult API’s, (iv) high tolerability, (iv) elegant feel, superior spreadability, rapid absorption, user convenience, (v) allow dispensing from airless pump containers and (vi) patented.
PAD™ Vehicles are manufactured in modules at room temperature. The rheology of PAD™ Vehicles can be tailored to match the required characteristics of feel, drag and finish.
PAD™ Vehicles enable release of the full potential of API’s.
Examples where key features of PAD™ Vehicles are enabling in formulation development